Effect of Insulin Deficiency on Low Density Lipoprotein Metabolism in Rabbits
- 1 January 1988
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 20 (01) , 11-14
- https://doi.org/10.1055/s-2007-1010737
Abstract
These studies have been carried out in rabbits with alloxan-induced diabetes in order to see if insulin deficiency affects low density lipoprotein (LDL) catabolism. The results showed that plasma LDL-cholesterol was lower in diabetic rabbits, associated with a fall in the cholesterol to protein ratio of LDL particles. In addition, 125I-LDL disappeared more slowly from plasma of diabetic rabbits, leading to a significant reduction in fractional catabolic rate and a decrease in residence time of 125I-LDL. These data demonstrate that LDL composition and catabolism are greatly altered as a consequence of insulin deficiency.Keywords
This publication has 0 references indexed in Scilit: