MODIFICATION OF THE BINDING-PROPERTIES OF MUSCARINIC RECEPTORS BY GALLAMINE
- 1 January 1983
- journal article
- research article
- Vol. 23 (3) , 551-557
Abstract
The interaction of gallamine with [rat] muscarinic receptors from different tissues was investigated. Gallamine binds to a site distinct from the conventional muscarinic ligand binding site and modulates the binding of agonists and antagonists to the conventional binding site. The effects of gallamine on the binding of muscarinic ligands are much greater in heart than in other tissues. These findings suggest the possibility of developing novel and selective muscarinic drugs.This publication has 14 references indexed in Scilit:
- The modes of action of gallamineProceedings of the Royal Society of London. B. Biological Sciences, 1981
- The character of the muscarinic receptors in different regions of the rat brainProceedings of the Royal Society of London. B. Biological Sciences, 1980
- Isomerization of the muscarinic receptor . antagonist complex.Journal of Biological Chemistry, 1979
- Guanine nucleotides modulate muscarinic receptor binding in the heartBiochemical and Biophysical Research Communications, 1979
- Cooperativity in ligand binding to dihydrofolate reductaseBiochemistry, 1978
- BINDING OF AGONISTS TO BRAIN MUSCARINIC RECEPTORS1978
- BINDING OF ANTAGONISTS TO BRAIN MUSCARINIC RECEPTORS1978
- Muscarinic acetylcholine receptors in developing chick heartJournal of Biological Chemistry, 1977
- RESPONSES OF ACETYLCHOLINESTERASE FROM TORPEDO MARMORATA TO SALTS AND CURARIZING DRUGS1966
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951