Specificity of the Tumor-Specific Transplantation Antigen Induced by JC Virus, a Human Polyomavirus
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in Intervirology
- Vol. 8 (3) , 182-185
- https://doi.org/10.1159/000148893
Abstract
The specificity of the tumor-specific transplantation antigen (TSTA) induced by JC virus was investigated by cross protection tests in weanling hamsters. Hamsters immunized with JC virus, BK virus, or SV40 were challenged 5 weeks later with known numbers of JC virus- or SV40-induced hamster tumor cells. Both the JC virus-immune and the SV40-immune hamsters showed resistance to challenge with homologous but not heterologous tumor cells, and the BK virus-immune hamsters were not resistant to either heterologous tumor cell. The TSTA induced by JC virus did not cross-react with that induced by SV40.Keywords
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