Dendrite Development Regulated by CREST, a Calcium-Regulated Transcriptional Activator
- 9 January 2004
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 303 (5655) , 197-202
- https://doi.org/10.1126/science.1089845
Abstract
The lasting effects of neuronal activity on brain development involve calcium-dependent gene expression. Using a strategy called transactivator trap, we cloned a calcium-responsive transactivator called CREST (for calcium-responsive transactivator). CREST is a SYT-related nuclear protein that interacts with adenosine 3′,5′-monophosphate (cAMP) response element–binding protein (CREB)–binding protein (CBP) and is expressed in the developing brain. Mice that have a targeted disruption of the crest gene are viable but display defects in cortical and hippocampal dendrite development. Cortical neurons from crest mutant mice are compromised in calcium-dependent dendritic growth. Thus, calcium activation of CREST-mediated transcription helps regulate neuronal morphogenesis.Keywords
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