Experimental Enteritis Cystica in Rats

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Abstract
Opened segments of small intestine, grafted to the abdominal wall of rats, mucosal side outward, revealed marked epithelial proliferative activity, with hyperplastic mucosal folds, polypoid excrescences, increased mucus secretion, and downgrowth of epithelium into and beyond the muscularis, with formation of mucus-filled cysts. The lesion was the result of long-standing, chronic, suppurative inflammation with shallow ulcerations, but preservation of the basal portion of the mucosal epithelium. The lesions, which were produced in 11 of 12 rats, sacrificed 5 to 14 mo. after the grafting, closely resembled colitis cystica profunda. Differentiation of these lesions from a mucus-secreting adenocarcinoma might be very difficult, especially on a small biopsy specimen.

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