Hypothalamic Hamartoma
- 6 January 1977
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 296 (1) , 7-10
- https://doi.org/10.1056/nejm197701062960102
Abstract
The presence of a hypothalamic hamartoma and precocious puberty in a 19-month-old boy provided an opportunity to study their relation. Excised tissue had the ultrastructural characteristics of an independent neuroendocrine unit — i.e., neurons containing neurosecretory granules and blood vessels with fenestrated endothelium and double basement membranes. Immunofluorescence studies using specific antibody to luteinizing-hormone-releasing factor showed antigenicity to the factor in the hamartoma.This publication has 14 references indexed in Scilit:
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