Ultrastructure of Morris Renal Tumors2

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Abstract
The transplantable Morris kidney tumors MK1, MK2, and MK3 were adenocarcinomas probably derived from proximal renal tubules of the rat. Ultrastructurally, the tumor cells resembled cells of pars recta of the proximal renal tubule. The neoplastic cells were polarized. Canalicular surfaces were covered by a modified brush border consisting of microvilli. Accumulations of basement membrane-like material were found in MK2 and MK3. Minor differences were seen in the structure and quantities of cellular organelles in individual tumors. Microbodies with central densities were found in all tumors. Catalase and D-amino-acid oxidase were active, though less active than in renal cortices from control rats.

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