Serum Creatinine Levels Correlate With Plasma Amyloid β Protein
- 1 July 2002
- journal article
- Published by Wolters Kluwer Health in Alzheimer Disease & Associated Disorders
- Vol. 16 (3) , 187-190
- https://doi.org/10.1097/00002093-200207000-00009
Abstract
The authors investigated the effect of renal function on plasma amyloid beta protein (Abeta) by analyzing the relationship between creatinine (Cr) and Abeta40 or Abeta42 in plasma from 59 normal control subjects (NC) and 220 Alzheimer disease (AD) patients. In all 279 subjects, Cr was significantly associated with Abeta40 (p < 0.001) and Abeta42 (p < 0.01), accounting for 7.3% and 3.1% of shared variance, respectively. Significant associations were also present in NC and AD groups separately. These results indicate that it may be useful to consider Cr levels when measuring plasma Abeta.Keywords
This publication has 8 references indexed in Scilit:
- Heritability of plasma amyloid β in typical late‐onset Alzheimer’s disease pedigreesGenetic Epidemiology, 2001
- Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's DiseaseJournal of Neuroscience, 2001
- Plasma amyloid ?-peptide 1-42 and incipient Alzheimer's diseaseAnnals of Neurology, 1999
- Increased plasma amyloid β protein 1–42 levels in Down syndromeNeuroscience Letters, 1998
- Alzheimer's soluble amyloid β is a normal component of human urineFEBS Letters, 1997
- Amyloid β-Peptide Is Transported on Lipoproteins and Albumin in Human PlasmaJournal of Biological Chemistry, 1996
- Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's diseaseNature Medicine, 1996
- Clinical diagnosis of Alzheimer's diseaseNeurology, 1984