The Relevance of 25‐Hydroxycalciferol Measurements in Sera of Patients with Renal Failure*

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Abstract
Iliac crest biopsies and serum specimens were obtained from 36 non-dialyzed uremic patients. The mean serum 25-hydroxycalciferol concentration of the patients was lower than that of normal subjects and a significant correlation was found between 25-hydroxycalciferol values and the severity of osteomalacia. Parathyroid osteopathy was significantly correlated with serum immunoreactive parathyroid hormone but not with serum 25-hydroxycalciferol values. While normal serum 25-hydroxycalciferol concentrations in uremic patients do not exclude the presence of osteomalacia, a low concentration is virtually diagnostic of this disorder.