T-cell-receptor beta- and I-A beta-chain genes of normal SWR mice are linked with the development of lupus nephritis in NZB x SWR crosses.

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Abstract
The incidence of nephritis in autoimmune New Zealand Black (NZB) mice is low, but when they are crossed with normal SWR mice, almost 100% of the female F1 hybrids (SNF1) develop lethal glomerulonephritis. To define the contribution of the normal SWR strain to the development of nephritis, we analyzed the association of the I-A.beta.-chain gene of Ia-encoding region, the T-cell receptor .beta. (TcR.beta.)-chain gene, and immunoglobulin heavy-chain allotype (IgH) with development of lupus nephritis in 165 .times. SWR crosses. We found that genes linked to the TcR and Ir gener loci of the normal SWR mice interacted with NZB derived genes, leading to the development of accelerated and severe nephritis in the N20 .times. SWR crosses.