Effect of Adrenaline, Noradrenaline and Octapressln® on Bleeding and Circulation In Ear Operations

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Abstract
Bleeding is perhaps the most harmful factor in modern otologic microsurgery. The side-effects of adrenaline are well known and therefore a study was made where Octapressin, or Octapressin and noradrenaline, was used to control bleeding at 90 ear operations. The results show that neither of the agents has the efficiency of adrenaline as far as hemostasis is concerned. Circulatory disturbances were slight when Octapressin was administered whereas adrenaline caused great changes in blood pressure and heart rate on patients under general anaesthesia. On the other hand, the best bleeding control was obtained with adrenaline. The authors suggest that administration of local anaesthetic especially with adrenaline should precede induction of general anaesthesia.