Mutagenicity in V79 Chinese hamster cells of n-alkanals produced by lipid peroxidation
- 1 January 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Mutagenesis
- Vol. 4 (4) , 277-279
- https://doi.org/10.1093/mutage/4.4.277
Abstract
The mutagenicity for mammalian cells of five n-alkanals produced by lipid peroxidation was tested in V79 Chinese hamster lung cells either at the hypoxanthine-guanine phosphoribosyltransferase locus as resistance to 6-thioguanine or at the Na/K ATPase locus as resistance to ouabain. The results show that propanal, butanal, pentanal and hexanal induced a dose-dependent increase in the frequency over controls of both 6-thioguanine- and ouabain-resistant mutants at concentrations ranging from 3 to 30 mM. With nonanal the same effects were observed with concentrations of 0.1–0.3 mM.This publication has 3 references indexed in Scilit:
- Methylglyoxal-induced mutation to 6-thioguanine resistance in V79 cellsMutation Research Letters, 1987
- Cytotoxicity, DNA fragmentation and sister-chromatid exchange in Chinese hamster ovary cells exposed to the lipid peroxidation product 4-hydroxynonenal and homologous aldehydesMutation Research/Genetic Toxicology, 1986
- Mutagenesis by N-acetoxy-2-acetyl aminofluorene of Chinese hamster V79 cells is unaffected by caffeineChemico-Biological Interactions, 1978