Sp1‐like transcription factors are regulators of embryonic development in vertebrates
- 25 May 2005
- journal article
- review article
- Published by Wiley in Development, Growth & Differentiation
- Vol. 47 (4) , 201-211
- https://doi.org/10.1111/j.1440-169x.2005.00797.x
Abstract
Sp1-like family is an expanding transcription factor family. Members of this family bind to the GC-box or GT-box elements in the promoter/enhancers and regulate the expression of the target genes. Currently, this family consists of at least nine members, which may act as a transactivator or a repressor on target promoters. Sp1-like transcription factors are expressed during development of vertebrate embryos in ubiquitous or tissue-specific manners and play various roles in embryonic development. This review mainly summarises their expression patterns and functions during vertebrate embryogenesis.Keywords
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