A PRELIMINARY STUDY ON THE EFFECT OF ALPHA-INTERFERON TREATMENT ON THE JOINT INFLAMMATION AND SERUM CALCIUM IN RHEUMATOID ARTHRITIS
- 1 June 1992
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 31 (6) , 405-408
- https://doi.org/10.1093/rheumatology/31.6.405
Abstract
A 12-week, double-blind controlled study comparing low dose α-interferon (5×105 iu, twice a week) and placebo was carried out to determine whether this drug has an immunomodulatory effect in rheumatoid arthritis. There were statistically significant improvements in the patients' joint score, C-reactive protein value and platelet count, without any side effects. Interferon-a caused an increase of serum calcium and a decrease of alkaline phosphatase. Thus, α-interferon requires further investigation as a possible additional useful treatment for rheumatoid arthritisKeywords
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