This is the 7th and youngest case of Alexander''s disease to be reported. Histologically, this condition is characterized by eosinophilic hyaline bodies (Rosenthal fibers) deposited in a subpial and perivascular band and distributed randomly throughout the white matter. Seen by electron microscopy, the hyaline bodies consist of irregular granular osmophilic masses contained within the cytoplasm of fibrillary astrocytes. They appear to arise from conglutination of altered glial filaments.