Hormone Receptors 5. Binding of Glucagon and Insulin to Human Circulating Mononuclear Cells in Diabetes Mellitus
- 1 January 1975
- journal article
- Published by Taylor & Francis in Endocrine Research Communications
- Vol. 2 (4-5) , 367-376
- https://doi.org/10.1080/07435807509089009
Abstract
Preparations of human peripheral mononuclear leukocytes, containing over 85% lymphocytes, specifically bound glucagon and insulin. Binding of physiological concentrations of both hormones was seen to be substantially diminished when cells were derived from either adult-type diabetics or individuals with a unilateral genetic history of diabetes.Keywords
This publication has 9 references indexed in Scilit:
- Glucagon: Role in the Hyperglycemia of Diabetes MellitusScience, 1975
- Demonstration that monocytes rather than lymphocytes are the insulin-binding cells in preparations of humah peripheral blood mononuclear leukocytes: implications for studies of insulin-resistant states in man.Proceedings of the National Academy of Sciences, 1975
- Glucagon secretion in unaffected monozygotic twins of juvenile diabeticsMetabolism, 1975
- Decreased Insulin Binding to Lymphocytes from Diabetic SubjectsJournal of Clinical Investigation, 1974
- Characterization of 125I-Glucagon Binding in a Solubilized Preparation of Cat Myocardial Adenylate CyclasePublished by Elsevier ,1974
- Hormone ReceptorsJournal of Biological Chemistry, 1974
- Insulin Receptors in Human Circulating Lymphocytes: Application to the Study of Insulin Resistance in Man*Journal of Clinical Endocrinology & Metabolism, 1973
- Abnormal Alpha-Cell Function in DiabetesNew England Journal of Medicine, 1970
- Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic RatsDiabetes, 1963