RANDOMIZED COMPARISON OF 5-FU ALONE OR COMBINED WITH MITOMYCIN AND CYTARABINE (MFC) IN THE TREATMENT OF ADVANCED GASTRIC-CANCER

  • 1 January 1982
    • journal article
    • research article
    • Vol. 66  (6) , 1263-1266
Abstract
In a prospective randomized study, 53 patients with advanced gastric cancer previously untreated by chemotherapy were randomly assigned to treatment with 5-FU [5-fluorouracil] alone or combined with mitomycin and cytarabine (MFC). The response rate with MFC was higher (28%) than with 5-FU alone (21%). The difference, however, was not statistically significant. Median response duration was practically identical with 5-FU (16 wk) and MFC (17 wk). There was no difference in median survival between the 2 groups (39 and 43 wk, respectively).