Thyroxine Biosynthesis and Thyroidal Uptake of I131 in Rats at The Onset of Hypoxia Exposure.

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Abstract
Summary Exposure of rats to a reduced pressure (380 mm Hg) simulating an altitude of 18,000 feet resulted in a markedly elevated I131 uptake in the thyroid, a relative increase in the amount of intrathyroidal I131 MIT and a lowered I131 DIT. The hypoxia induced alteration of thyroid hormone synthesis was found to be a transient response since the I131 MIT/DIT ratio returned to control levels after 60 hours of exposure. A possible mechanism which could account for these thyroidal changes is discussed.