Conservation of the human telomere sequence (TTAGGG)n among vertebrates.
- 1 September 1989
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 86 (18) , 7049-7053
- https://doi.org/10.1073/pnas.86.18.7049
Abstract
To determine the evolutionary origin of the human telomere sequence (TTAGGG)n, biotinylated oligodeoxynucleotides of this sequence were hybridized to metaphase spreads from 91 different species, including representative orders of bony fish, reptiles, amphibians, birds, and mammals. Under stringent hybridization conditions, fluorescent signals were detected at the telomeres of all chromosomes, in all 91 species. The conservation of the (TTAGGG)n sequence and its telomeric location, in species thought to share a common ancestor over 400 million years ago, strongly suggest that this sequence is the functional vertebrate telomere.This publication has 25 references indexed in Scilit:
- Recombination occurs during telomere formation in yeastNature, 1989
- Telomeric repeat from T. thermophila cross hybridizes with human telomeresNature, 1988
- Eukaryotic nuclear telomeres: Molecular fossils of the RNP world?Cell, 1988
- The telomeres of the linear mitochondrial DNA of tetrahymena thermophila consist of 53 bp tandem repeatsCell, 1986
- Rates of DNA Sequence Evolution Differ Between Taxonomic GroupsScience, 1986
- Identification of a specific telomere terminal transferase activity in tetrahymena extractsCell, 1985
- A family of inverted repeat sequences and specific single-strand gaps at the termini of the Physarum rDNA palindromeCell, 1980
- A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in TetrahymenaJournal of Molecular Biology, 1978
- Circular dichroism evidence for G·U and G·T base pairing in poly[r(G-U)] and poly[d(G-T)]Biopolymers, 1977
- Repeat sequence of a hermit crab satellite deoxyribonucleic acid is (-T-A-G-G-)n.(-A-T-C-C-)nBiochemistry, 1974