TUBERCULIN SKIN REACTIONS IN MICE HYPERSENSITIZED BY VACCINATION WITH LIVING AVIRULENT TUBERCLE BACILLI

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Abstract
Mice vaccinated subcutaneously with water-in-oil emulsions of living, avirulent tubercle bacilli (H37Ra) developed immediate and delayed hypersensitivities to tuberculoprotein detectable and distinguishable by skin tests performed with this antigen. The former, an anaphylactic type of hypersensitivity, could be suppressed readily by specific desensitization or by treating the animal with tripelennamine hydrochloride (Pyribenzamine) or cortisone. The immediate reaction was a rapidly developing edematous skin swelling which subsided before the reaction due to delayed hypersensitivity had developed significantly. The latter-classic tuberculin allergy-could be specifically suppressed only by a series of desensitizing injections. It was not affected by tripelennamine hydrochloride but was counteracted by cortisone. The delayed reaction in the skin developed several hours after challenge and was characterized principally by induration and necrosis. The delayed hypersensitivity was transferred passively from hypersensitive to normal mice with thymus-gland and lymph-node homogenates but not with serum.

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