Serum Elastase Inhibitor. Levels in Animal and Human Sera, including Selected Disease States.

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Abstract
Reproducible serum elastase- inhibitor levels can be determined providing the incubation period of the system is not longer than one hour. The inhibitor resides at the alpha1 -globulin albumin junction of electrophoretically fractionated serum. The level in humans is independent of age. Average values for males is slightly higher than for females. Levels in sera of chicken, rabbit, guinea-pig, rat, mouse, sheep, dog, and monkey are broadly comparable to those of human serum. Inhibitor is greatly elevated in sera of human females during the third trimester of pregnancy, and variously and moderately elevated in a number of disease states. It is not diminished in arteriosclerosis.