FUNCTIONAL COMPARISON OF BLOOD AND GINGIVAL INFLAMMATORY POLYMORPHONUCLEAR LEUKOCYTES IN MAN

  • 1 January 1977
    • journal article
    • research article
    • Vol. 27  (1) , 152-158
Abstract
Polymorphonuclear leukocytes from the human gingival crevice (CREV-PMN) have a defective phagocytic capacity when compared with peripheral blood polymorphonuclear leukocytes (PB-PMN) from the same individual. In a study of 14 clinically healthy subjects, significantly smaller numbers of CREV-PMN phagocytosed fewer Candida albicans blastospores as compared with PB-PMN. The intracellular killing capacity of the 2 cell populations was similar. Removal of specific antibody but not complement significantly depressed blastospore uptake by both cell types. The intrinsic defect of the CREV-PMN is probably acquired in vivo and may be a general property of PMN from inflammatory sites.

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