Substance P Analog, DiMe-C7: Evidence for Stability in Rat Brain and Prolonged Central Actions
- 8 January 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 215 (4529) , 188-190
- https://doi.org/10.1126/science.6171884
Abstract
A metabolically protected analog of substance P, [pGlu5-MePhe8-MeGly9]SP(5-11) (DiMe-C7), was approximately equipotent with substance P in causing increased locomotor activity after microinfusion into the ventral tegmental area of rat brain, but the effects of DiMe-C7 on behavior were considerably prolonged. There was little metabolic degradation of tritiated DiMe-C7 for up to 1 hour after infusion, whereas tritiated substance P was completely degraded within 10 minutes.This publication has 9 references indexed in Scilit:
- Tritiated peptides. 12. Synthesis and biological activity of [4-3H-Phe8]substance PJournal of Medicinal Chemistry, 1982
- The behavioural effects of a novel substance P analogue following infusion into the ventral tegmental area or substantia nigra of rat brainBrain Research, 1982
- Synthesis and Biological Properties of Enzyme‐Resistant Analogues of Substance PEuropean Journal of Biochemistry, 1981
- Purification and Characterisation of a Membrane‐Bound Substance‐P‐Degrading Enzyme from Human BrainEuropean Journal of Biochemistry, 1981
- Substance P as a Transmitter CandidateAnnual Review of Neuroscience, 1980
- Substance P: In vitro inactivation by rat brain fractions and human plasmaBiochemical Pharmacology, 1979
- Behavioral activation induced in the rat by substance P infusion into ventral tegmental area: Implication of dopaminergic A10 neuronesNeuroscience Letters, 1979
- Increased dopamine metabolism in rat striatum after infusions of substance P into the substantia nigraBrain Research, 1978
- Increased spontaneous activity following substance P infusion into A10 dopaminergic areaNature, 1978