Morphological changes of basophils in immunological reactions—effect of sodium cromoglycate
- 1 June 1975
- journal article
- Published by Wiley in Clinical and Experimental Allergy
- Vol. 5 (2) , 181-187
- https://doi.org/10.1111/j.1365-2222.1975.tb01851.x
Abstract
The morphological changes in blood basophils, from patients with bronchial asthma, were studied in vitro during immunological reactions, with particular reference to interaction with anti‐IgE. Anti‐human IgE results in an absolute reduction in basophil numbers in buffy coat preparations as well as basophil cytoplasmic degranulation. An increase in the numbers of pear‐shaped (A‐form) basophils is also observed. Sodium cromoglycate impairs all these anti‐IgE induced basophil changes, providing further insight into the mechanism of action of this compound in bronchial asthma.Keywords
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