β-Adrenergic Inhibition of Human T Lymphocyte Rosettes

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Abstract
The cyclic nucleotides adenosine and guanosine monophosphate (CAMP and CGMP)1 have been reported to affect significantly the magnitude of cellular and humoral in vitro immune responses. Mitogenic lymphocyte stimulation (1, 2), lymphocyte-mediated cytotoxicity (LMC) (3, 4) and the effect of migration inhibitory factor on target cells (5) are inhibited by β adrenergic stimulants of intracellular CAMP, and dibutyryl CAMP. CGMP has been shown to enhance LMC (4). In vitro antibody synthesis has recently been shown to be inhibited by CAMP and enhanced by CGMP (6). Furthermore, CAMP has been reported to alter significantly mammalian cell morphology in vitro (7). Since the cyclic nucleotides have profound effects on the morphology and function of cells, we chose to study the effects of dibutyryl CAMP and the β adrenergic stimulant isoproterenol on the human T lymphocyte's binding affinity to sheep red cells (E rosettes).

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