Discussion: Immunology, cellular pathology, genetics

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Abstract
The commonest approaches to identify specific genetic factors include positional cloning studies that involve collections of families with multiple affected individuals or analysing affected sibling pairs so that linkage analysis can be performed. One genome-wide scan in 178 Icelandic patients reported an LOD score of 2.17 on chromosome 16q, whereas conditional on paternal transmission to affected individuals, the LOD score was 4.19. Recent studies of patients with PsA in Newfoundland suggest that variants within the CARD15 locus on chromosome 16q contribute to disease susceptibility.

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