Monoamine oxidase inhibitors from a fungus, Emericella navahoensis.
- 1 January 1988
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 36 (2) , 670-675
- https://doi.org/10.1248/cpb.36.670
Abstract
Norsolorinic acid, averufin and 6,7,8-trihydroxy-3-methylisocoumarin were isolated from Emericella navahoensis as metabolites having monoamine oxidase (MAO)-inhibitory action. Norsolorinic acid inhibited MAO in mouse liver non-competitively when kynuramine was used as a substrate, and its IC50 was 0.3 .mu.M. The inhibition constants (Ki) for MAO-A and -B in mouse liver were 0.24 and 0.68 .mu.M, respectively. On the other hand, Ki values for MAO-A and -B in mouse brain were 2.9 and 0.32 .mu.M, respectively. Inhibitory potencies towards MAO of some anthraquinone derivatives were also examined.This publication has 3 references indexed in Scilit:
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