Blocking the Receptor for Interleukin 10 Protects Mice from Lethal Listeriosis

Open Access

1 April 2001

journal article
Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy

Vol. 45 (4) , 1312-1314
https://doi.org/10.1128/aac.45.4.1312-1314.2001

Abstract

High doses ofListeria monocytogenesovercome the ability of a normal mouse to control the infection, due to massive bacterial replication. Treatment with an anti-interleukin 10 (IL-10) receptor monoclonal antibody prevented the fatal course of infection with high doses of bacteria. This work shows that blocking the receptor for IL-10 may have useful therapeutic applications.

Keywords

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