EXCITOTOXICITY AS A STOCHASTIC PROCESS
- 1 April 1995
- journal article
- review article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 22 (4) , 297-298
- https://doi.org/10.1111/j.1440-1681.1995.tb02001.x
Abstract
SUMMARY: 1. Neuronal death following excitotoxic insult appears to be a stochastic process involving transition through an intermediate biochemical state.2. Hydrogen ion accumulation in the hours after toxic glutamate exposure may indicate that this transition has occurred.Keywords
This publication has 8 references indexed in Scilit:
- Excitatory Amino Acids as a Final Common Pathway for Neurologic DisordersNew England Journal of Medicine, 1994
- Changes in intracellular pH associated with glutamate excitotoxicityJournal of Neuroscience, 1993
- Mechanisms of nitric oxide-mediated neurotoxicity in primary brain culturesJournal of Neuroscience, 1993
- Intracellular calcium levels during the period of delayed excitotoxicityJournal of Neuroscience, 1993
- Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neuronsJournal of Neuroscience, 1992
- Effects of excitotoxin exposure on metabolic rate of primary hippocampal cultures: application of silicon microphysiometry to neurobiologyJournal of Neuroscience, 1992
- Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrationsJournal of Neuroscience, 1990