Transcapillary Loss, Equilibrium Time, Half-Return Time of Thiocyanate and Heavy Water in the Forearm.

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Abstract
A method is presented for determining the net bidirectional exchange of permeable tracer substances across the capillary walls of the human forearm. In the early period of transit the maximum net transcapillary loss for thio-cyanate was 49 [plus or minus] 19% and for deuterium oxide 90 [plus or minus] 4%. The equilibrium time or period of net loss averaged 111 [plus or minus] 66 seconds for SCN and 130 [plus or minus] 86 seconds for D2O. Equilibrium times for both substances were related directly to blood flow. The half-return time for SCN averaged 3.4 [plus or minus] 3.0 times the equilibrium time. In the cases in which simultaneous measurements were made the half return time of D2O averaged twice that of SCN.