Increase in Tγ Lymphocytes in B‐Cell Chronic Lymphocytic Leukaemia

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Abstract
A significant increase in the proportion (mean 38 % ± 9.3 SD) and absolute number of Tγ (suppressor) lymphocytes was observed in 13 patients with chronic lymphocytic leukaemia (CLL) compared with 20 normal controls (mean 19 % ± 6.5). Conversely, the proportion of Tμ (helper) lymphocytes was lower in CLL (mean 27 % ± 9.3) than in the controls (mean 40 % ± 4), although the absolute numbers were normal or increased. It is suggested that an imbalance of T‐lymphocyte subsets controlling B‐lymphocyte differentiation may be relevant in the pathogenesis of CLL or some of its associated features.