Characterization of uterine heterogeneous nuclear ribonucleic acid and the effect of oestradiol-17β on its synthesis
- 15 June 1978
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 172 (3) , 587-593
- https://doi.org/10.1042/bj1720587
Abstract
An early response to the administration of oestradiol-17 beta to immature rats is a dramatic stimulation in the synthesis of uterine hnRNA (heterogenous nuclear RNA). High-molecular-weight fractions of the hnRNA were purified and subfractionated on poly(U)-Sepharose into fractions that differed in their poly(A) content and their size profile on polyacrylamide gels. Oestrogen treatment of the rats stimulated the synthesis of all three fractions of high-molecular-weight hnRNA, but the kinetics of synthesis, degree of stimulation and size distribution of the newly synthesize RNA differed in each fraction.This publication has 23 references indexed in Scilit:
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