Effects of phlorizin on glucose, water and sodium handling by the rat kidney.

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Abstract
The effect of phlorizin on glucose, water and Na handling by the kidney in anesthetized rats was investigated, using clearance techniques, during infusion of saline (200 .mu.l min-1) or saline to which low (0.1 .mu.mol kg body wt-1 ml-1) or high (1.0 .mu.mol kg body wt-1 ml-1) doses of phlorizin had been added. Phlorizin increased absolute and fractional excretion of glucose, urine osmolality and negative free water clearance; and reduced urine flow rate, glomerular filtration rate (GFR), absolute and fractional excretion of Na, absolute excretion of Na, absolute excretion of K and absolute and fractional rates of glucose reabsorption. Phlorizin apparently had sites of action and effects additional to those on glucose transport in the proximal tubule. Within each series there was a positive correlation between Na and glucose reabsorption, but rate of glucose reabsorption was different between each series although Na reabsorption was not. Since Na and glucose reabsorption correlated with GFR, they may be related via GFR. For the whole kidney any effect of glucose on Na transport was small relative to total renal handling of Na.

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