THERAPEUTIC RESPONSE OF HUMAN-TUMOR XENOGRAFTS IN NUDE-MICE TO TAXOL

  • 1 January 1983
    • journal article
    • research article
    • Vol. 297  (13) , 597-600
Abstract
To study the antitumor activity of taxol (a diterpene of the taxane type) isolated from Yew: Taxus baccata L (Taxacae), human tumors implanted as xenografts in athymic mice were used. Swiss nude mice were treated s.c. (12.5 mg/kg per injection per day for 5 consecutive days out of 7, over 3 wk). Treatment by taxol of a liver metastasis of a breast tumor, a tongue primary tumor and a skin metastasis of bronchial carcinoma gave statistically significant results (0.01 > P < 0.001 and P < 0.001). Taxol showed a moderate antitumor activity against a transplanted primary tumor of the colon.

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