CEREBRAL MYCOSIS

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Abstract
A clinico-pathological report of four cases of cerebral mycosis is given. The clinical manifestations were variegated. In two patients the symptoms simulated an intracranial tumor. A third patient suffered from a meningo-encephalo-myelopathy of obscure etiology, while sparse symptoms and signs were present in the fourth. The disease was fatal in 3 cases. One patient was cured by neurosurgical intervention. Clinically the conditions were misinterpreted. In two cases the diagnosis was an unsuspected finding at autopsy. A preliminary diagnosis of fungal infection was made on frozen section from surgical samples. Formation of granulomas were found a conspicuous feature in all the cases. The causative organisms were identified by histopathological studies and verified by cultures in 2 cases as Aspergillus fumigatus and Candida tropicalis. In the other cases the diagnosis was based upon the identification of Histoplasma capsulatum and Nocardia in histopathologic sections only. The histologic identification of fungi and the differential diagnostic problems are discussed.

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