Outcomes Following Liver Transplantation for Seronegative Acute Liver Failure: Experience During a 12-Year Period With More Than 100 Patients

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Abstract
Seronegative hepatitis is a common cause of acute liver failure (ALF) requiring liver transplantation. The primary aim of this study was to examine outcomes following transplantation in this group and to identify factors associated with early ( P = .009; odds ratio, 1.2; 95% confidence interval, 1.0-1.3). Recipient age >50 ( P = .015; odds ratio, 4.2; 95% confidence interval, 1.3-14.1) and non-Caucasian recipient ethnicity ( P = .015; odds ratio, 4.9; 95% confidence interval, 1.2-19.2) were other variables associated with early death on multivariate analysis. This study specifically examined factors that determine the early outcome of transplanted seronegative ALF patients. In conclusion, we found that donor and recipient factors identify patients who have a high chance of early death after transplantation.