Chemical mutagenesis testing in Drosophila: I. Comparison of positive and negative control data for sex‐linked recessive lethal mutations and reciprocal translocations in three laboratories
- 31 December 1983
- journal article
- research article
- Published by Wiley in Environmental Mutagenesis
- Vol. 6 (2) , 189-202
- https://doi.org/10.1002/em.2860060207
Abstract
As part of the validation phase of the Drosophila melanogaster segment of the National Toxicology Program, a comparison has been made of positive and negative controls for sex‐linked recessive lethal mutations and reciprocal translocations from three laboratories. This comparison involves approximately 700,000 spontaneous recessive lethal mutation tests, 70,000 spontaneous translocation tests, and screens for genetic damage induced by N‐nitrosodimethylamine and β‐propiolactone. Spontaneous frequencies for lethal mutations and translocations were homogeneous in the laboratories regardless of solvent or broods sampled. Inhomogeneity was observed in induced frequencies among laboratories, but the variation was no greater than that found within a laboratory.Keywords
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