Magnesium Binding as an Explanation of the Mode of Action of Novobiocin
- 27 April 1962
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 136 (3513) , 316-317
- https://doi.org/10.1126/science.136.3513.316
Abstract
Novobiocin affects a wide variety of biochemical and biological processes in bacteria, whereas most other antibiotics seem to affect one specific process. All of the processes known to be affected by novobiocin require magnesium ions, and in a number of cases magnesium deficiency mimics the action of the antibiotic. Evidence is presented that novobiocin complexes with magnesium ions.Keywords
This publication has 4 references indexed in Scilit:
- Effect of novobiocin on permeability of Escherichia coliArchives of Biochemistry and Biophysics, 1959
- Novobiocin as uncoupling agentCellular and Molecular Life Sciences, 1958
- STUDIES ON THE MODE OF ACTION OF NOVOBIOCINJournal of Bacteriology, 1956
- Effects of Magnesium on Cellular Division in BacteriaScience, 1953