Synthesis and effects on arginase and nitric oxide synthase of two novel analogues of Nω-hydroxyarginine, Nω-hydroxyindospicine and p-hydroxyamidinophenylalanine
- 1 January 1996
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 7,p. 645-648
- https://doi.org/10.1039/p19960000645
Abstract
Two novel amino acids, Nω-hydroxy-D,L-indospicine and p-hydroxyamidino-D,L-phenylalanine, have been synthesized in four steps from tert-butoxycarbonylglycine. Both compounds act as good inhibitors of arginase, Nω-hydroxyindospicine being one of the best inhibitors of this enzyme known so far (IC50= 50 µmol dm–3). In contrast, with brain NO synthase the two compounds are almost without effect.Keywords
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