SUBACUTE BACTERIAL ENDOCARDITIS TREATED UNSUCCESSFULLY WITH SULFAPYRIDINE AND HEPARIN

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Abstract
This case is presented as one of subacute bacterial endocarditis in which treatment with sulfapyridine and heparin was unsuccessfully attempted. Unfortunately, this case had the fatal outcome usual in the vast majority of instances of this disease, but it is felt nevertheless that in the evaluation of a new form of therapy it is important to report the failures as well as the successes and to point out some of the practical difficulties in proceeding with a course of treatment theoretically desirable to stem the infectious process. Efforts at treatment have been stimulated by the discovery of new chemical agents. Friedman, Hamburger and Katz1reported the use of heparin in the treatment of subacute bacterial endocarditis, this drug being chosen on account of its supposed capacity to prevent clot or thrombus formation. At the same time a report was published by Kelson and White2on the use of

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