Experimental study on thermal damage to dog normal brain
- 1 January 1994
- journal article
- research article
- Published by Taylor & Francis in International Journal of Hyperthermia
- Vol. 10 (4) , 553-561
- https://doi.org/10.3109/02656739409009357
Abstract
We investigated the temperature changes and their distribution in agar phantoms and dog normal brains induced by 8 MHz radiofrequency interstitial hyperthermia and observed the histological changes, with respect to the neurons and myelinated nerve fibres, induced by the same heat source in dog normal brains. We also examined the change of blood-brain barrier permeability using Evans blue solution. The heating limits of dog normal brain were 42°C for 45 min or 43°C for 15 min and the breakdown of the BBB was observed at 43°C for 60 min.Keywords
This publication has 10 references indexed in Scilit:
- Blood-brain barrier alteration after microwave-induced hyperthermia is purely a thermal effect: I. Temperature and power measurementsSurgical Neurology, 1991
- Interstitial Radiofrequency HyperthermiaThermal Medicine(Japanese Journal of Hyperthermic Oncology), 1989
- Radiofrequency Hyperthermia for Malignant Brain Tumors: Preliminary Results of Clinical TrialsNeurosurgery, 1987
- A theoretical comparison of the temperature distributions produced by three interstitial hyperthermia systemsInternational Journal of Radiation Oncology*Biology*Physics, 1986
- Interstitial hyperthermia and iridium brachytherapy in treatment of malignant gliomaJournal of Neurosurgery, 1986
- Microwave Hyperthermia for Brain TumorsNeurosurgery, 1985
- Localized Hyperthermia in the Treatment of Malignant Brain Tumors Using an Interstitial Microwave Antenna ArrayIEEE Transactions on Biomedical Engineering, 1984
- Feasibility of Microwave Hyperthermia for Brain Tumor TherapyPublished by S. Karger AG ,1983
- Interstitial microwave hyperthermia for brain tumorsJournal of Neuro-Oncology, 1983
- Hyperthermia for Brain TumorsNeurosurgery, 1981