An Alternative Route to 2-Bromo-Estradiols and 2-Iodo-Estradiols From Estradiol
- 1 January 1987
- journal article
- research article
- Published by CSIRO Publishing in Australian Journal of Chemistry
- Vol. 40 (2) , 303-309
- https://doi.org/10.1071/ch9870303
Abstract
Through careful choice of reaction conditions, alkylation of estradiol with chloromethyl methyl ether may yield either the 3,17β-bis(methoxymethy1) ether or the 3-methoxymethyl ether derivative. Treatment of either of these protected estradiols with s- butyllithium, then with trimethylsilyl chloride affords, regioselectively, the 2-trimethylsilyl derivatives which can conveniently be converted into 2-bromo-or 2-iodo-estradiol.Keywords
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