Two-Stage Cooperative T Cell Receptor-Peptide Major Histocompatibility Complex-CD8 Trimolecular Interactions Amplify Antigen Discrimination
Open Access
- 20 January 2011
- Vol. 34 (1) , 13-23
- https://doi.org/10.1016/j.immuni.2010.12.017
Abstract
No abstract availableKeywords
This publication has 55 references indexed in Scilit:
- The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsivenessNature, 2010
- TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinityNature, 2010
- The αβ T Cell Receptor Is an Anisotropic MechanosensorJournal of Biological Chemistry, 2009
- Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based MotifCell, 2008
- Spatial and Temporal Dynamics of T Cell Receptor Signaling with a Photoactivatable AgonistImmunity, 2007
- Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76Nature Immunology, 2005
- Actin and agonist MHC–peptide complex–dependent T cell receptor microclusters as scaffolds for signalingThe Journal of Experimental Medicine, 2005
- Direct observation of ligand recognition by T cellsNature, 2002
- Signal transduction by lymphocyte antigen receptorsCell, 1994
- Tickling the TCR: selective T-cell functions stimulated by altered peptide ligandsImmunology Today, 1993