Measles skin test and serologic response to intradermal measles antigen

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Abstract
A measles antigen test was performed intradermally on 150 children and adults. Seventy-seven percent of patients who had been previously vaccinated with either attenuated or killed measles virus vaccine reacted with erythema in an area of more than 5 mm at the skin-test site. Twenty percent of patients with a history of clinical measles gave a similar reaction. No reactions were observed in a group of 19 patients with a history of neither vaccination nor clinical measles. There was no relationship demonstrated between skin-test reaction and humoral antibodies. The intradermal injection of measles antigen failed to induce a booster antibody response in over half the individuals studied. It is concluded that the material tested has no real clinical usefulness.

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