THE CHEMICAL NATURE OF THE AMPHIBIAN ORGANIZER

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Abstract
Since cephalin possesses many of the solubility properties which have been indicated for the amphibian organizer, it was thought desirable to test the capacity of cephalin in inducing secondary medullary plates. The cephalin was obtained from calf''s brains by the use of ether, alcohol, and acetone, and was necessarily impure. It was mixed with kaolin to form a paste and small amounts were placed in the blastocoeles of early gastrulae (Mexican axolotl). In 8 of 24 surviving eggs there was clear induction of a secondary medullary plate. There is thus a possibility that a cephalin or perhaps one or more of the impurities which may accompany it have the inductive properties of the amphibian organizer.

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