Influences du mode d'irradiation, de l'hypophysectomie, des hormones gonadotropes et des radio-protecteurs chimiques sur la reponse de l'ovaire de lapine aux rayons rontgen

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Abstract
Under given experimental conditions, a single dose of 2500 r is required to obtain sterilization in the female rabbit ovary and, in the majority of instances, complete destruction of the follicle apparatus. Fractionation of the radiation into 5 equal consecutive daily doses lowers the sterilization threshold dose to 2000 r and the dose for complete destruction to 2250 r. Prior administration of gonado-tropins and, to a certain degree, hypophysectomy, give the same result. On the other hand, intraven injn., immediately before irradiation, of a "radiation protective agent", such as beta-mercapto-ethylamine, increases these 2 threshold doses considerably[long dash]to 2750 r for sterilization and to over 3000 r for complete destruction. It appears that the chemical "radiation protective agent" acts, to some extent at least, on a cellular level.