ACTIVATION OF B-LYMPHOCYTES BY MYCOPLASMA MITOGEN(S)

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 34  (4) , 715-720
Abstract
Various strains of the murine mycoplasma Mycoplasma neurolyticum induced extensive blast transformation of mouse lymphocytes, comparable in strength to mitogenicity exerted by these mycoplasma species on rat lymphocytes. The data summarized in this report demonstrate that this mitogenic effect was non-specific. Lymphoid cells from mycoplasma free, germ-free mice were activated to the same extent as those lymphocytes obtained from conventionally bred animals. Lymph node cell suspensions obtained from athymic nude mice were strongly activated by M. neurolyticum mitogen. Mouse thymocytes and mouse T[thymus-derived]-cell enriched populations were not stimulated by these mitogens. M. neurolyticum probably activates mouse B [bone marrow-derived] lymphocytes.