Corticotropin-Releasing Hormone: From Endocrinology to Psychobiology
- 1 January 1989
- journal article
- review article
- Published by S. Karger AG in Hormone Research
- Vol. 31 (1-2) , 66-71
- https://doi.org/10.1159/000181089
Abstract
Corticotropin-releasing hormone (CRH) is a brain neuropeptide which coordinates the endocrine, autonomic and behavioral responses to stress. We review the abnormal response to exogenous CRH in various psychiatric syndromes, including major depression and anorexia nervosa. We also contrast pituitary responses to CRH in patients with depression versus Cushing’s disease. We hypothesize that CRH may play a role in the pathogenesis of various psychiatric syndromes which are characterized during their course by the symptom of depression.Keywords
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