An investigation of the role of intraluminal proteolytic enzymes and intracellular enzyme inhibitors in ulcerative colitis.

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  • 1 August 1972
    • journal article
    • Vol. 53  (4) , 359-73
Abstract
The output of trypsin and chymotrypsin was determined in 26 patients with ulcerative colitis and 8 with polyposis coli, each of whom had undergone total colectomy and ileostomy. Measurements were made in each subject over periods ranging from 3 to 8 days on a standard diet. The output of each enzyme was lower in the group with ulcerative colitis, but serial post-operative measurements suggested that this was due to the relatively poorer nutritional status of patients in this group, and no consistent difference was apparent between individuals in both groups whose ileostomy had been established more than one year before the measurements were made.