SURFACE-ANTIGENS OF THE MURINE CYTOSTATIC PERITONEAL MACROPHAGE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 41  (1) , 187-193
Abstract
By rosetting techniques, peritoneal exudate cells (PEC) from mice stimulated i.p. with starch have been shown to be a mixed population of cells consisting of the following subpopulations of cells: 75% FcR [Fc receptor], 26% C3R [complement component 3 receptor], 18% Ig+, 29% Ia+,Ig- and 5% Thy-1+,Ig-. By separating rosetting from nonrosetting cells, it was possible to establish the phenotype of the PEC which was cytostatic for tumor cells. This cell possessed receptors for Fc and C3 but lacked surface Ig, the Thy-1 antigen and I-region controlled antigens and was NSE [nonspecific esterase] positive. By presently available criteria, the cytostatic PEC can be identified as a macrophage. The lack of Ia distinguishes this type of macrophage from the antigen-presenting macrophage which bears Ia.